{"id":6064,"date":"2021-07-29T11:42:00","date_gmt":"2021-07-29T15:42:00","guid":{"rendered":"https:\/\/www.therecoveryvillage.com\/?page_id=6064"},"modified":"2022-05-23T18:46:37","modified_gmt":"2022-05-23T22:46:37","slug":"using-ibogaine","status":"publish","type":"page","link":"https:\/\/www.therecoveryvillage.com\/opiate-addiction\/treatment-rehab\/using-ibogaine\/","title":{"rendered":"Using Ibogaine for Opiate Detox"},"content":{"rendered":"\n

Prescription narcotics and heroin are opioid drugs derived from the opium poppy plant.<\/h3>\n\n\n\n

In order to understand opiate addiction treatment<\/a>, it\u2019s important to understand how opiates work in the body. These drugs bind to opioid receptors in the brain, effectively blocking pain and producing a calming and pleasant result. When abused, users may experience a euphoric effect, or \u201chigh,\u201d when dopamine (one of the neurotransmitters responsible for pleasure) levels are increased in the brain.<\/p>\n\n\n\n

Ibogaine is among the substances that may be used to address opioid addiction<\/a>. There is some controversy surrounding its use, due to its illegal status in the US.<\/p>\n\n\n\n

Opioid Abuse<\/h2>\n\n\n\n

Opioids are considered highly addictive, as users develop a tolerance and even physical and psychological dependency to them when they are used regularly over a period of time. Opioids may quickly become the focus of obsession, negatively affecting health, work, school or family obligations, and interpersonal relationships.<\/p>\n\n\n\n

The Centers for Disease Control and Prevention<\/a> (CDC) calls prescription drug abuse an epidemic, as 44 people die in America every day from a prescription opioid overdose. In fact, drug overdose is the leading cause of injury death in the United States.<\/p>\n\n\n\n

Drug abuse costs American society $181 billion a year in health care and legal costs as well as lost workplace production, the National Institute on Drug Abuse<\/a> (NIDA) reports. Over 2 million American adults aged 12 or older were addicted to opioid prescription drugs in 2012, and another 467,000 were addicted to heroin, as published by NIDA<\/a>.<\/p>\n\n\n\n

Addiction is a chronic, complex and relapsing brain disease that is highly treatable.<\/a> Opioid abuse and dependency are commonly treated with psychotherapies and 12-step programs, often after a period of detox. Opioid drugs make chemical changes in the brain, and the first step in recovery is to reach a healthy and stable physical balance, often with the aid of medications during detox.<\/p>\n\n\n\n

Medically Assisted Detox<\/h2>\n\n\n\n

Medically assisted opioid detox<\/a> is performed in a safe and supervised environment and it seeks to manage the uncomfortable flu-like symptoms and emotional side effects, including anxiety, insomnia, restlessness, depression, and irritability, that accompany opioid withdrawal<\/a>. During medical detox, partial opioid agonists such as buprenorphine or long-acting opioid narcotics like methadone<\/a> are commonly used, in order to slowly taper off opioid drugs in a controlled manner.<\/p>\n\n\n\n

At appropriate doses, partial agonists and opioids with long half-lives can help keep cravings and opioid withdrawal symptoms<\/a> to a minimum. These drugs are still opioid narcotics, however, with the potential for diversion and abuse. Researchers have long been searching for alternative medications or methods to aid in substance abuse treatment. Ibogaine is potentially a drug that may help circumvent compulsive drug use behaviors, essentially resetting the brain as it relates to substance abuse and staving off withdrawal symptoms.<\/p>\n\n\n\n

Ibogaine in the United States<\/a><\/h2>\n\n\n\n

Commonly used in initiatory ceremonies in western Central Africa and harvested from the Tabernanthe iboga plant, ibogaine is a psychoactive alkaloid. In the United States, the Drug Enforcement Administration<\/a>, or DEA, currently considers ibogaine a Schedule I controlled substance with no accepted medicinal uses and a high potential for abuse and dependency due to its hallucinogenic properties.<\/p>\n\n\n\n

While ibogaine has been around and used for many purposes over the years, it was Howard Lotsoff who is first attributed with using it to attempt to treat heroin addiction<\/a> on himself in the 1960s, as reported by the New York Times<\/a>. Lotsoff became an advocate for the drug, claiming it stops drug cravings and promotes detox without withdrawal symptoms. In 1986, he received a patent for ibogaine in capsule form and worked with European psychiatrists and doctors to treat cocaine and opioid addiction with ibogaine.<\/p>\n\n\n\n

Lotsoff\u2019s drug seemed to be working as two-thirds of 30 patients worldwide remained abstinent from drugs for several months and even years in contrast to the general 75 percent relapse rate within six months with traditional methods. Initially, NIDA was interested in ibogaine, and the U.S. Food and Drug Administration (FDA) approved clinical trials for using the drug in opioid dependency treatment; however, a lack of funds and the death of a patient using ibogaine in the Netherlands effectively halted research in the mid-1990s and ibogaine remains a banned substance in America today.<\/p>\n\n\n\n

Around the time the United States declined to further ibogaine research, private clinical trials and ibogaine treatment clinics sprang up in other parts of the world. Deborah Mash, an addiction specialist, and neuroscientist from the University of Miami, opened a private research center in the Caribbean in the 1990s where she tested ibogaine on 300 addicts. According to Mash, and published by BBC World Service<\/a>, all patients showed an effect on their addiction from the ibogaine treatment and 70 percent remained in recovery for months and years after treatment. However, it is unclear if Mash compared her results to patients using an alternative treatment.  Researchers today are attempting to isolate noribogaine, one of the metabolites of ibogaine, and hoping to test its effectiveness as a potential legal alternative to ibogaine for addiction treatment.<\/p>\n\n\n\n

How Ibogaine works<\/a><\/h2>\n\n\n\n

Ibogaine remains controversial in part due to its mind-altering and hallucination-inducing effects. While scientists are still studying exactly how ibogaine works in the brain, it seems to prevent excitotoxic damage to neurons. Certain drugs of abuse, like opiates, can cause excitotoxic damage.<\/p>\n\n\n\n

When used for opioid detox, ibogaine generally follows the following timeline according to the journal Current Drug Abuse Reviews:<\/p>\n\n\n\n